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HRT Issues

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Hey, im Emma, 23 mtf :)

im on hrt since november and im taking estradiol . They took blood from me 2 weeks ago and they cant fins estrogen in my blood! Also, my testosterone hasnt gone done much. Has anybody had similar experiences? My doctor said, she never saw something like that before and first thought i wouldnt take my pills. I was trying gel now but two days afterwards i felt depressed so i stopped taking it and resumed with the pills. 
Im very desperate and hope to find people with similar issues and hopefully solutions. 

Ty in advance ~Emmy :)

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  • Forum Moderator

@Emmy_1003 To let you know - I removed the actual dosage you are taking as that is something we request not to list.


It's hard to determine how HRT will effect each body. You've still not been on for a long time and I would hope you provider is adjusting dosages and hopefully has you on a T blocker. Work closely with your provider to determine the best mix to help you.


All in all it is OK. You're doing fine. Not everyone sees changes quickly. You'll do fine, give it patience and work closely with your provider and follow their instructions closely and don't think more is better without their approval. I did and it caused other issues.





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Welcome Emma! Glad you're here. I have only been on HRT for two weeks, I haven't had any follow-up blood work done yet, so take what I say with this in mind. Is it possible the lab results were wrong or faulty? Maybe another test might reflect a change in estrogen. Whether on HRT or not, men & women have both estrogen and testosterone, so you should reflect some level. Did you have an estrogen level in your preliminary blood work? Have you noticed any physical changes? While you're still early to being on HRT, on page 44, the WPATH SOC v7 lists loss of libido, loss of spontaneous erections as changes starting to occur about 1-3 months. You're a bit young to experience baldness. As Heather said, this takes time, although at times I wake up hoping it magically changed me overnight.




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Hi @Emmy_1003


we’re all different….sorry that’s obvious


Your age (early 20s) might be a factor why your T is fighting back longer than you want.  Consider that statement an unprofessional guess.

You’re probably all good in the short long run if you stay with it.  

It’s not the same as you, but want to share my experience:  My T went immediately down, and E way up. With only starting  estradiol, no blocker.  
BUT I mention this because, in my case, I did not notice even subtle physical or emotional changes for nearly a year, despite the responsive hormone readings.  I’ve encountered people with lower E/higher T who had much more dramatic feminizing body results from HRT than me.

I want you to have hope, and know inside that these changes can happen many mysterious ways.  It’s not necessarily gonna happen the same way you thought, or the way it worked for someone else.

Please keep working with Drs and keep learning about HRT yourself.  This effort, over time…..will yield your new life. if you choose to stay the path.


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My prescriber told me that with the pills, they have to go through your liver before the estrogen gets where it needs to go, and the liver can end up rejecting either a little or a lot of the estrogen, and the amount it may or may not reject can be very unpredictable from person to person. I'm no doctor of course, but maybe that could be part of what's going on.

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Try dissolving the pill under you tongue. It goes directly into the bloodstream and my doctor says it is safer.

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51 minutes ago, BrandiBri said:

Try dissolving the pill under you tongue. It goes directly into the bloodstream and my doctor says it is safer.

That's exactly what I do, as directed by my provider, because of my cardiac issues. At my one month follow-up, my estrogen was basically"perfect." No T blocker, either, and that level was nearly on target. Now, that number could also be because, at my age, it could have been somewhat lower already. I was fortunate enough to realize breast growth within about 3-4 months. 


Be patient. I'm sure you will start seeing positive results in the near future.

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