Jump to content
  • Welcome to the TransPulse Forums!

    We offer a safe, inclusive community for transgender and gender non-conforming folks, as well as their loved ones, to find support and information.  Join today!

Sandrena gel applications tips and questions.


Christina87

Recommended Posts

Hi 👋

 

I recently started using Sandrena  *mg saches again. I use*** saches a day, morning and night in combination with my Progynova and Spironolactone. I rotate every day in three areas, the thigh left and right also stomach belly area.

My question is, what's the best way to get the MOST benefit from the transdermal gel (Sandrena)

 

I have a few questions. Please feel free to answer all or any of the below.

 

1) Is it true that the inner thigh is actually more effective than the top or outer thigh as an application site?

 

2) Is it true that you can apply the gel to other areas of the body,(other than only the lower trunk as advised in the information leaflet), such as forearm and upper arm. And if so, is it the same effectiveness.

 

3) Is it true that spreading it in a smaller area on the skin than the recommended two hands size area is more concentrated and potent, potentially more strongly absorbed (estrogens) and thus more effective. 

 

4) Is regular exfoliating of the application site a good or useful way to get the most benefit from Sandrena.

 

5) Is it ok to get dressed after 5 minutes, 10 minutes or longer? 

 

6) Is it possible to add a third sache (midday) in addition to the morning and evening dose to boost the overall effectiveness and are there doctors/endos that prescribe this dose.

 

Also I'd love to hear any positive things or reviews about Sandrena, and any tips/advice.

 

Thankyou in advance.

 

Link to comment
  • Forum Moderator

I would suggest most of your questions are best answered by your doctor.   

I use a topical E and clean the area well before application.  I also try to leave as much time as possible before dressing.

 

Hugs,

 

Charlize

Link to comment

Thankyou for your response. Would you say 10 minutes is sufficient if drying it with a wind fan to speed it up a bit?

The problem is, my doctor only has limited knowledge on hormones and not an endocrinologist. The endos here take 9 months to get an appointment. Lol.

Link to comment

Hi Christina,

 

Great questions and post!

 

I've been using Sandrena gel for a few years, morning and evening. I've learned quite a bit about it along the way but Charlize is right that some or all of your questions are best answered by your doctor. That's particularly true for question 6) about dosing. So anything I put here should please be treated as non-medical and anecdotal. However, here goes.

 

I really like the sandrena gel. I like the steady state estrogen it gives me and I feel very adjusted to it. I mention this because I had serious fluctuation issues with injections and I am very glad I'm no longer taking pills because of liver concern (I know you're also taking progynova) and clotting. The gel seems to be a very safe method.

 

Personally I haven't noticed much difference as to where it's applied, with the exception of the abdomen. If you put it on there, which the leaflet says to do sometimes, then I am not convinced it does absorb so well because of the fat. I may be wrong about that so it's just my experience but my levels dropped when I applied it there. Otherwise I doubt inner or outer makes a lot of difference if you've got good circulation and you're fit. I expect the inner thigh is proposed firstly because that's where your femoral artery runs and secondly because you're less likely to rub onto someone else or something else. I am due blood tests a month from now so I can update on that but my levels have been good with outer thigh.

 

So ... I apply morning to the outer thigh and then in the evening I apply to the arm on the opposite side of my body. This is partly for practicality: in the morning I'm sitting up in bed for half an hour or so with a coffee so it's ideal. In the evening I may be anywhere, and applying to the arm is easy.

 

I always exfoliate, or rather, I have a lady razor in my shower and almost daily run this over some part of my body or other. It's not that I'm hairy, I just like smooth skin. And natal females do also use razors ;)  I've not encountered any issues with this. So basically I shower first thing and then apply the morning gel. I have two showers a day because I always have a workout in the middle of the day.

 

Whatever the leaflet says, I do spread it a over good open hand width (two small closed hands) - so a reasonable area. I guess maybe 4" x 10". I don't think I'm allowed to tell you the dose (am I?) but it's not just one sachet in the morning.

 

do slightly rub it in. I was advised to do this, whatever the leaflet says, and  it undoubtedly helps it to dry more quickly. When I say 'slightly' I mean just enough to stop it looking like I've lathered myself in turkey fat but it's still a thin film or sheen, and still very tacky.

 

I have to say that although occasionally I've had to put clothes over the top after 10 minutes, and the leaflet says this is fine, I try not to. Usually I don't cover it for half an hour, especially in the morning. And I don't shower or bath again for at least six hours.

 

I hope some of this helps?

 

xx

 

 

 

Link to comment

Hi Tilly and thankyou so much for your response. Sorry for the slow reply.

Your information was very helpful and very thorough! I like Sandrena too and that's why I went back on it after a few years. I feel somehow it's right for me at the moment. After nearly 2 weeks back on it my breasts feel slightly sore and are perky around the nipple area. Hopefully if all goes well I'll have a little more breast growth but if not I'll feminize up again slightly now that I'm back on a higher dose. 

Thanks.   

Please feel free to msg me back. I'm a little nervous. Thanks.

Link to comment

Christina, I have also used Sandrena for some time, and can pass on my experiences rather than qualified medical advice. My doctor admits when he doesn't know things, and has used me as a sort of test subject at times. We tried different application techniques, and then did blood tests to see if there were differences. I was applying day and night, and used different locations each time. We tried the places recommended in the literature, and some other spots with thinner skin and more blood supply, but the blood levels were the same for each. The instructions say to spread over an area equivalent to 2 palms, and leave to dry, but I found this to be time lost waiting to dry, so we tried rubbing it in until it was almost all absorbed and only needing a couple of minutes to dry, and the blood tests results were the same.

 

We had read of higher rates of absorption from thinner skin areas, but concluded this just meant that there would be more of an initial spike in levels, but overall, not more effective. The sites recommended will absorb it all, but maybe a bit slower, which can be better as it is more even. Some people have difficulty with transdermal absorption, and need to use another cream in preparation to facilitate absorption, but I never did this so can't comment. 

 

I liked Sandrena, but needed a high dose to get the target levels, and it was a chore to apply to multiple places morning and night, so a couple of years ago we switched to implanted pellets, which I really like. (I preferred this option to injections). I am also near Melbourne, my doctor is in Geelong, and specialises in trans medicine, but admits the available knowledge is poor, so he is open to learning. 

 

Hugs,

 

Allie

 

Link to comment
5 hours ago, Ivy said:

I'm curious about the implants.

Ivy, I have a tiny pellet about 3 mm dia, and maybe 10mm long made up at a compounding pharmacy under prescription from my doctor. He then make a small incision in my lower abdomen, and places the pellet(s) in my fat layer. It takes a couple of weeks for it to become fully active, but then it delivers estrogen at my target range for up to 15 months, and I don’t have to do anything but blood tests every 8 to 10 weeks. 

 

It is not a mass produced drug here in Australia, and not on the subsidised health system, so is a little more expensive, but the convenience of not having to worry about hormones for mor than a year is well worth it, and I do get higher E levels. I have read of women in the US getting pellets through compounding pharmacies also.

 

Hugs,

 

Allie

Link to comment
  • Forum Moderator
9 minutes ago, AllieJ said:

I have read of women in the US getting pellets through compounding pharmacies also.

This is new information for me. I am aware of HRT implants placed in the arm but not in the abdomen. The procedure in the arm lasts up to a few years and is much larger. I wonder if the placement and smaller size is less invasive than in the arm in regards to scarring and issues?. This sounds very promising. The more options available, the better.

Link to comment
4 hours ago, Susan R said:

This sounds very promising. The more options available, the better.

Yeah.  I would certainly be interested is it was available to me.

For one thing, it would make it harder for the forced detransition crowd.

Link to comment
On 6/18/2023 at 2:12 PM, AllieJ said:

Christina, I have also used Sandrena for some time, and can pass on my experiences rather than qualified medical advice. My doctor admits when he doesn't know things, and has used me as a sort of test subject at times. We tried different application techniques, and then did blood tests to see if there were differences. I was applying day and night, and used different locations each time. We tried the places recommended in the literature, and some other spots with thinner skin and more blood supply, but the blood levels were the same for each. The instructions say to spread over an area equivalent to 2 palms, and leave to dry, but I found this to be time lost waiting to dry, so we tried rubbing it in until it was almost all absorbed and only needing a couple of minutes to dry, and the blood tests results were the same.

 

We had read of higher rates of absorption from thinner skin areas, but concluded this just meant that there would be more of an initial spike in levels, but overall, not more effective. The sites recommended will absorb it all, but maybe a bit slower, which can be better as it is more even. Some people have difficulty with transdermal absorption, and need to use another cream in preparation to facilitate absorption, but I never did this so can't comment. 

 

I liked Sandrena, but needed a high dose to get the target levels, and it was a chore to apply to multiple places morning and night, so a couple of years ago we switched to implanted pellets, which I really like. (I preferred this option to injections). I am also near Melbourne, my doctor is in Geelong, and specialises in trans medicine, but admits the available knowledge is poor, so he is open to learning. 

 

Hugs,

 

Allie

 

This whole discussion has been so interesting. Everyone's contributions are adding so much. I found what you've posted here Allie really valuable.

 

A few months back my endo had to increase my Sandrena dose because my estradiol levels had dropped below the right range for some reason. I have blood tests in a few weeks so we'll see what happens. I agree that there would come a point where I'd want to look for an alternative. The pellets sound great.

Link to comment
29 minutes ago, Tilly said:

This whole discussion has been so interesting. Everyone's contributions are adding so much. I found what you've posted here Allie really valuable.

 

A few months back my endo had to increase my Sandrena dose because my estradiol levels had dropped below the right range for some reason. I have blood tests in a few weeks so we'll see what happens. I agree that there would come a point where I'd want to look for an alternative. The pellets sound great.

Thanks Tilly, sometimes estrogen receptors for some reason become less active, so the same dose will yield a lower blood reading. We found that pills for a short time can wake up receptors and even when stopped, the gels uptake is better. This varies for different people, but I have read many accounts of it working.

 

I'm on a UK pellet forum and the pellets there seem to only last 3 months or even less whereas my pellets have lasted 15 months on average. It must just be a difference in the pharmacy methods.

 

Hugs,

 

Allie

Link to comment

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Who's Online   2 Members, 0 Anonymous, 31 Guests (See full list)

    • T876
    • SamC
  • Recently Browsing   0 members

    • No registered users viewing this page.
  • Forum Statistics

    • Total Topics
      79.3k
    • Total Posts
      751.1k
  • Member Statistics

    • Total Members
      11,305
    • Most Online
      8,356

    bea23
    Newest Member
    bea23
    Joined
  • Today's Birthdays

    1. Andi Shay
      Andi Shay
      (53 years old)
    2. Fabiola
      Fabiola
      (46 years old)
    3. ghost
      ghost
      (60 years old)
    4. Julia Marie
      Julia Marie
      (32 years old)
    5. juliasvw
      juliasvw
      (52 years old)
  • Posts

    • missyjo
      they're very cute but if I find them with my lace panties or costly bras ill...speak harshly to them for 2 days   hugs
    • susannah
      Several years ago, I stated here that I will not start estradiol even though I was pushing boundaries toward HRT.  I started to take spironolactone but had to stop.  Also, I have been on finasteride for a few years now.  I finally broke down and started estradiol last year.  After 3 months, my body started to show small feminization.  I developed breast buds that were about the size of quarter on both sides.  Even though these changes were quite desirable, I decided to stop HRT.  I was terrified of the consequences of transitioning.     After 3 months, I started hrt again but stopped after 2 months.  I restarted again but stopped yet again after 3 months.  My body changes seem to happen faster each subsequent time.     I am so conflicted right now.  I would love to be on estradiol yet I am afraid to do so.  It has been 5 months since my last estradiol tablet.  My desire to restart hrt is getting stronger.  When I started estradiol, it feels like I let the genie out of the bottle.  I did not know what I was missing.     Has anyone else had similar experience?  Honestly, I do not know where to go from here.     Susannah
    • awkward-yet-sweet
      I finally did something today that I've wanted to do for a long time, but haven't had the courage to try.  I got my nipples pierced!  Also got hip dermals and belly button done.  I held off for years for multiple reasons, not the least of which lately was the uncertainty of how it will affect how I pass.  Don't see a lot of boys with those kinds of piercings.  But I figure I'm androgynous so I can pull off the look well enough.  And also, our faith community isn't exactly in favor of tattoos and piercings.    One of my partners did the job - she's pretty good at it.  She's done VCH piercings for my female partners (kind of a wedding tradition here.)  I was a bit nervous, but it wasn't bad.  And my husband said I look cute, so that's eased my mind a bit too. 
    • awkward-yet-sweet
      I think there's a difference between banning a book and saying it isn't suitable for academic purposes.  Students can read whatever they want from the library on their own time.  And if they end up doing a book project they can probably pick something to use that isn't on the list of things teachers can use in classes.  I suspect that the removal of some of these books is due to sex scenes inside.  Toni Morrison's stuff, for example.  I read both Beloved and Song of Solomon when I was in high school.  I didn't find the sex parts of books to be particularly lurid, but I definitely found Beloved to be demonic and disturbing.  I'm glad that book isn't approved for use in our county's high school.  And its not like the schools are against multicultural literature.  For example, Chinua Achebe's Things Fall Apart is read by just about everybody (although my husband says that you have to reread the book as an adult to really get the benefit of it.)    I think we have to look at why we have an English or literature class.  Why are some books useful and others not?  For example, Shakespeare's plays and poems have historical and literary value.  Teachers spend time on those, but probably not Tom Clancy or Nicholas Sparks novels.  Teachers want students to experience literary styles, cultures, and teach about the structure of writing.  Selecting what is useful is a subjective judgement, of course.  The thought that Beloved or Song of Solomon doesn't make the grade doesn't seem odd to me at all. 
    • awkward-yet-sweet
      Yeah, we find messes like that too sometimes.   Multiple house cats.  They are quiet at 3am, but 11pm is the hour where they all go nuts.  We call it the "hour of scampering."  One of them actually runs into walls, and I've found them wearing dirty laundry.  Ever seen a cat turn a pair of panties into a shirt? 
    • Nicoleeolee
      3:30 in the morning is basically when my cat goes on crack for a while…. I actually believe she’s chasing ghost away because there’s no other reason for her to reach running through the entire house and tearing up everything…… I know this is about what we’re wearing but my cat was wearing this when I woke up this morning
    • Ivy
      When a book is banned, it does make one curious about it. And being banned by the right wing is kind of an endorsement.
    • Ivy
      sometimes that's all that saves their lives. I mean… dragging me out of bed at 03:30 and expecting me to feed you… now?  
    • VickySGV
      I would have suggested but not demanded that you go to your nearest hospital or just to the a local clinic or even police station but I would have listened as well for what it took.  It is no shame to get medical attention, nor is it a shameful thing to get into a care situation.  Here where I live our sheriff will send out a counseling team to see how serious your situation really is, again, no shame attached.  It sounds to me that the police who came to you did the same thing there. We do have the related Discord Site Chat Site for help if you just need to chat a depression off, it is a bit funky, but when you are feeling OK, fire it up for the down times.   https://www.transgenderpulse.com/chat/   I have Cyclic Major Depressive Syndrome myself which comes and goes.  I do have IRL human sources through a couple of LGBTQ Centers around me.  Again, I set up the system in my good moments and found out they were fine for those times too.    I do not know who you called but if it is one of the numbers on on our site here, please let one of us on the Admin staff know by PM which it was. 
    • LaurenA
      The cops were here.  I was able to talk them off without getting arrested.  Every time this happens I swear I'll never do this again.
    • KymmieL
      Wow, That is BS. You call for help. Then they don't want to give any. that is sure nice. Lauren is there anyone else you can call. We are here if you need help. Just talk to us. We don't judge. Only thing we would tell you to check in to is a resort to pamper yourself.   Take care, Kymmie
    • LaurenA
      I was depressed and called a hotline.  All they want me to do is check myself in.  I hung up on them and expect the police to show up at any moment.
    • Davie
      Reading is resistance’: students and parents take on DeSantis’s book bans. Florida governor’s constant attacks on the education system have led to an increasing backlash from a wide range of people. Upon learning that her AP English teacher might not be able to use Song of Solomon by Toni Morrison in the syllabus this year, Mogul came up with an idea to start a book club. Her aptly named Banned Books Club was established last month, featuring titles that have been removed from public school circulations in Florida, and meets at a celebrated Miami bookstore called Books & Books. A range of people of different ages and backgrounds, including a handful of Mogul’s peers, an audio producer and an English teacher attend. https://www.theguardian.com/us-news/2023/sep/23/florida-desantis-book-ban-school-student-parent
    • Nicoleeolee
      You’re so sweet…. thank you so much…. I appreciate the encouragement. I have worked very, very hard. It’s an interesting life having a cat as a roommate, right. I mean overall they’re terrible terrible roommates. You have to clean up after them constantly.. They never chip in for dinner? They won’t go get a job. …😂.   Luckily, they’re really cute and furry.
    • Willow
      Hi, where did the week go?  So, last Sunday I gave a sermon for our on-line church.  Wednesday, I worked 6 to 2.  When I got home I sat for a little while then I proceeded to make two loaves of bread for a church bake sale.  Friday, I worked at our church’s annual yard sale as a cashier.  And today I opened our store, 4:15 to 12:15.  Yes, I was tired.  I’m not used to getting up that early.  I had a short nap this afternoon.  We are going to a local pub for dinner then I’ll watch the Buckeyes vs Notre Dame football game.  I’m a bit of a channel surfer so I don’t know that I’ll watch it from beginning to end.  It depends on what else is on, but I will keep track of the game.     Next week at work we will be doing a whole lot of changes.  Making certain everything in the store shelves is correctly located per marketing guidelines.  Then overnight Tuesday we will pull off all of the shelf tags and put up all new ones.  The entire store in one overnight.  That should be interesting.  I think that is supposed to be the first step in a total makeover.  Well, maybe step two if you count going to overnight unattended fueling as a part of it.  Eventually, we are supposed to get all new drink machines, move the candy aisle, add additional store shelves and much more.  This fall should be interesting.   We had tropical storm Ophelia make a backside visit here last night.  Rain and wind.   Willow
  • Upcoming Events

Contact TransPulse

TransPulse can be contacted in the following ways:

Email: Click Here.

To report an error on this page.

Legal

Your use of this site is subject to the following rules and policies, whether you have read them or not.

Terms of Use
Privacy Policy
DMCA Policy
Community Rules

Hosting

Upstream hosting for TransPulse provided by QnEZ.

Sponsorship

Special consideration for TransPulse is kindly provided by The Breast Form Store.
×
×
  • Create New...