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Study: HRT May Lead to Higher Risk of Porphyria


Carolyn Marie

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Charlize

It seems from reading this article that it is caused by using too much E.  Smoking appears to be a factor as well.  Perhaps this is one reason why i was told that i should not smoke again.  In my case i certainly didn't want to get hooked again anyway!  

Certainly another reason to be careful and work with an experienced doctor.  

 

Hugs,

 

Charlize

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I'm not on HRT yet, but I wonder if any of our Members have experienced some of the side-effects mentioned?  Acne, skin issues (sun blisters?), skin darkening?  (the changes in hair distribution seem a normal effect)

Its good to know these symptoms I think, specially if just starting HRT or a change in therapy ?


 

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Yikes, I am already very sensitive to the sun. Not a full blown allergy, but highly sensitive. I do not go outside without a good slathering off sun block. 
 

I am glad that the authors stressed the importance of ensuring that the potential for this side effect was carefully balanced against the need for gender affirming care. 
 

Kay, I already had skin issues related to the sun, so I avoid it as much as possible; that being said, I haven’t noticed any increase in sensitivity at 8 months on hrt. I can tell you, that in general, my skin is less oily and as result, the blackheads and acne I had have almost cleared up entirely. 

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Tory Aoi

Hmm, I do tend to burn easily, but I avoid excessive sun and use sunscreen often anyways.  As I never smoked, hopefully that helps me out as well.

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Alexxiss

My doc is extra-cautious. So seeing as the woman was bumped from 0mg Progesterone/Day to XXmg/D and from XXmg to XXmg Oral Est/D is incredibly alarming. It appears to be no wonder what with her daily smoking and 2 beers/D for a month and this "supratherapeutics" that her regimen became injurious. It alarms me that the articles find her jump from XXmg/D to XXmg/D to be "within published guidelines," implying that such a drastic change is advisable, especially to this high risk patient. I also find it sad that the women chose to continue smoking and drinking despite doctors advising against whilst they pulled her HRT and subverted it with XXMG Hydroxychloroquine. It would appear she has underlying substance issues not involved with HRT or PCT.

 

Thanks for the read Carolyn Marie! I had fun with this one.

Edited by Jani
Discussion of Dosages not allowed despite being cited in the attached article.
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