Jump to content
  • Welcome to the TransPulse Forums!

    We offer a safe, inclusive community for transgender and gender non-conforming folks, as well as their loved ones, to find support and information.  Join today!

Odds of prostate cancer in post-HRT trans women


Dana Michelle

Recommended Posts

Does anyone have any idea what the odds are of transgender women getting prostate cancer? Prostate cancer runs in my family. I asked my endocrinologist and she said there has not been enough research to determine the odds. I wonder if there is at least anecdotal reports of what the odds are. Does anyone know? I found an article that said there have only been four reported cases of prostate cancer in transgender women, all of which started HRT after age 45 (I started at 36) https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00439-8/fulltext. However, there could be many more unreported cases.

 

I do plan to have prostate cancer screening once I am 50 years old, but I am still wondering if anyone has any idea what the odds are. Given that 1 in 7 cis men (and presumably pre-HRT trans women) gets prostate cancer, it seems like if the odds were as high for post-HRT trans women, it would be known. Also, does anyone know how the odds of post-HRT trans women getting prostate cancer compares to cis women getting Skene's gland cancer? I read that Skene's gland cancer makes up 1 in 30000 female genital cancers, but that doesn't say what the odds are of cis women (and presumably, pre-HRT trans men) getting it (just the odds that, if a cis woman will get genital cancer, it will be in the Skene's gland).

 

Also, for the sake of trans men, it would also be worth asking what the odds are of post-HRT trans men getting Skene's gland cancer.

 

Link to comment
  • Forum Moderator

Dana I don't believe there has much study on this subject.  I am one of those 1 in 7 that got it and had it rectified years ago.  I would think (my opinion only) that taking estrogen would lessen the chances.  I've read anecdotal evidence that it shrinks testes so it might also affect this gland as well.

Link to comment
1 hour ago, Dana Michelle said:

Does anyone have any idea what the odds are of transgender women getting prostate cancer? Prostate cancer runs in my family. I asked my endocrinologist and she said there has not been enough research to determine the odds. I wonder if there is at least anecdotal reports of what the odds are. Does anyone know? I found an article that said there have only been four reported cases of prostate cancer in transgender women, all of which started HRT after age 45 (I started at 36) https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00439-8/fulltext. However, there could be many more unreported cases.

 

I do plan to have prostate cancer screening once I am 50 years old, but I am still wondering if anyone has any idea what the odds are. Given that 1 in 7 cis men (and presumably pre-HRT trans women) gets prostate cancer, it seems like if the odds were as high for post-HRT trans women, it would be known. .

 

 

As Jani, I have had prostate cancer. I had the surgery to remove it and 2 years later ADT + radiation. It also runs in my family. I am not a doctor, but have talked to people on almost every English speaking prostate cancer website out there. I am on Lupron, which shuts down testosterone and estrogen, except from the adrenal glands. It causes both the testes and the prostate to shrink if you still have them. Odds of cancer should be substantially reduced at your age by HRT, but not to zero. I have no idea how it compares to Skene's gland cancer

 

Hugs,

Mike

Link to comment
  • Forum Moderator

I've read that it reduces your risk, but as others have said, there haven't been a ton of studies. I couldn't tell you exactly how much.

 

We're hard to study considering that we're on the rare side and kind of reclusive. Like bigfoot.

 

Hugs!

Link to comment
  • 1 month later...

This topic is something I am researching and I am in the process of discussing with the medical profession. I read somewhere on the internet, must be true,  that prostrate cancer in transgender women is extremely rare, in the magnitude of less than 10 per year? If true there are a number of explanations for this phenomenon. Transgenders die earlier of other causes before prostrate cancer comes into play and or HRT hormones slow down the progression of the disease so that other causes of morbidity comes into play.  I do not know if this internet rumor  applies to fully transitioned SRS transgender women or transgender women just on HRT? Given my advance age of 67 and just starting HRT this past March, family history of prostrate cancer,  both father and my father's father were dead at 72 from prostrate cancer related causes,  I am of the mind that the risk posed by HRT might  outweighed by benefits of HRT.  2 percent increased risk of stroke and DVT verses near certain prostrate cancer. I know that this a huge leap to think that being on HRT might be able to prevent prostrate cancer  given prostate cancer possible genetic component which might equates to inevitable certainty of getting prostrate cancer. My hairball unsubstantiated medical ignorant wishful thinking theory is that HRT hormones and blockers along with castration will slow down disease progression to the point where the transgenders dies from other causes before prostrate cancer come into play.  I suppose we could start by just looking  at transgender cause of death statistics and then compare them against other demographics to see if further investigation is be warranted. This is a subject for a  PHD thesis. 

Link to comment

Hi Rami,

 

As a person who had prostate removed and salvage radiation 2 years later (this year) I will comment. Of course I am not an expert or doctor. I found out age 62 that I had almost the most aggressive cancer possible with a large part of my prostate involved. Many in my family have had this cancer, but never this young.

 

My point is this: If you have no cancer to start with, I think HRT might keep you from getting it or at least make it less likely. However, I had a pretty low PSA when it was discovered, so it is possible you could already have it and not know it yet. Just proceed with caution, although obviously most never have this problem.

 

I am on Lupron to shut down hormones for 2 years starting right before the radiation early this year. I had an endocrinologist ready to give me estrogen. My urologist won't give the OK for estrogen because he says it could cause my cancer to grow again if radiation didn't get it all. Lets just say that conversation did not go well during my last visit with him! I am still pretty bummed out. I told him I would wait for a little while, but if I didn't have estrogen soon after my hopefully upcoming GCS, I might have another doctor by then. YMMV

 

Hugs,

Mike

Link to comment

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Who's Online   4 Members, 0 Anonymous, 122 Guests (See full list)

    • awkward-yet-sweet
    • Adrianna Danielle
    • Abigail Genevieve
    • MirandaB
  • Recently Browsing   0 members

    • No registered users viewing this page.
  • Forum Statistics

    • Total Topics
      80.6k
    • Total Posts
      768k
  • Member Statistics

    • Total Members
      12,014
    • Most Online
      8,356

    Quillian
    Newest Member
    Quillian
    Joined
  • Today's Birthdays

    1. Bowie Ellis
      Bowie Ellis
      (19 years old)
    2. Damien Mcknight
      Damien Mcknight
      (18 years old)
    3. JJ
      JJ
      (77 years old)
    4. KathyLauren
      KathyLauren
      (70 years old)
    5. memyselfandwe
      memyselfandwe
      (44 years old)
  • Posts

    • Abigail Genevieve
      On the way back to her desk she was interrupted by six short, urgent conversations that had to be attended to. Then she slipped into the women's room and locked the stall door.  She took a deep breath, then another, and allowed herself to shake for five minutes,  Then deep breathing, ten in and ten out, stretch up, touch the floor, neck rolls and she was fine. She used the toilet and a woman knocked and said, "Taylor, are you okay?"   "Ready to conquer the world!"  on her way out she found her makeup was fine.  Three stalls, two sinks.  If she ever designed a women's room with three stalls, there would be four sinks, with plenty of space to plunk your stuff down between them.   She met a deferential Karen.  "Here is the branding I came up with," she said.  And she went back to working as hard as Brenda and Mary, who looked up worriedly and then went back to the proposal.   Shortly before 5:00 she received an email with the title Consolidation and Compensation.  In it she learned that the position of office manager was eliminated, and the current office manager was to become the chief executive officer. The former CEO, along with the CFO, the chief legal officer, and sundry staff, had been terminated, per the Board of Directors.  Effective immediately everyone would receive a base salary of $20,000 with a commission to be set by the individual's supervisor.  Each supervisor would be given a certain percentage to distribute.  Most functions they had been handled would be outsourced as needed.   "The question of what profit was made last year is frequent enough to be answered.  The company lost over 500,000 in fiscal 2023.  At this point further cuts are not anticipated.  We will be strategically adding positions that will enhance our profits. Hard work is expected of everyone."   Her two web guys had been complaining because their games had been remotely uninstalled.  After the memo came out they were absolutely silent.  That gave her an idea, and after an exchange of emails they were reassigned to maintenance out at the plant, effective tomorrow morning.  There were lots of weeds that needed pulling, if nothing else. That email went out after they left early, for the day.  The maintenance foreman was a no-nonsense type who did not tolerate slacking, and they would learn a thing or two.  This also freed up two spaces for her to put new people.
    • MaeBe
      So…I didn’t know your Facebook avatar was public. So, on my birthday, a couple people used a group avatar message to wish me a happy birthday…and now my Facebook friends can see a short video of my female avatar dancing with an old friend’s and another with my uncle’s avatars. So am I “Facebook out” now? 😬
    • Davie
      No, they are not. Truth wins in the end and this report is full of lies that poison the whole thing: see this: "Dr. Cass Backpedals From Review: HRT, Blockers Should Be Made Available it's said. Dr. Cass's latest statements are likely to cast more doubt on the validity of the study, which has come under fire for disregarding substantial evidence on trans care." https://www.erininthemorning.com/p/dr-cass-backpedals-from-review-hrt?publication_id=994764&post_id=143743897&isFreemail=true&r=rebf4&triedRedirect=true I hope Dr. Cass wins The Mengele Award for it.
    • Adrianna Danielle
      Boyfriend and I went to a support group for spouses dating or married to a transgender person on Tuesday night for the first time.It was amazing meeting other couples like us.One was a genetic woman whom has been dating a transgender male for the first time and she is supporting his transition.Us,they were amazed by us agreeing on something we said,love and acceptance have brought us together
    • Abigail Genevieve
      By which I mean there is a cultural stereotype of what a man is, and one of what a woman is.  Even worse, of what a transgender person is.   You be you.   I read of a boy who thought he was a girl because he did not adhere to some (rather toxic) conceptions of what it means to be a man, so he decided he was a girl.  He was told he didn't have to conform to stereotype and got happy. "You mean I don't have to transition?" He didn't want to, and was relieved.   Once upon a time if you were transgender they told you either you transition or die.   Incorporate the best of what it means to be a man and the best of what it means to be a woman as much as you possibly can, and let the rest go.  Be fully human. Be alive. Don't conform to some cultural crud.
    • Abigail Genevieve
      On the way back to her desk she was interrupted by six short, urgent conversations that had to be attended to. Then she slipped into the women's room and locked the stall door.  She took a deep breath, then another, and allowed herself to shake for five minutes,  Then deep breathing, ten in and ten out, stretch up, touch the floor, neck rolls and she was fine. She used the toilet and a woman knocked and said, "Taylor, are you okay?"   "Ready to conquer the world!"  on her way out she found her makeup was fine.  Three stalls, two sinks.  If she ever designed a women's room with three stalls, there would be four sinks, with plenty of space to plunk your stuff down between them.   She met a deferential Karen.  "Here is the branding I came up with," she said.  And she went back to working as hard as Brenda and Mary, who looked up worriedly and then went back to the proposal.   Shortly before 5:00 she received an email with the title Consolidation and Compensation.  In it she learned that the position of office manager was eliminated, and the current office manager was to become the chief executive officer. The former CEO, along with the CFO, the chief legal officer, and sundry staff, had been terminated, per the Board of Directors.  Effective immediately everyone would receive a base salary of $20,000 with a commission to be set by the individual's supervisor.  Each supervisor would be given a certain percentage to distribute.  Most functions they had been handled would be outsourced as needed.   "The question of what profit was made last year is frequent enough to be answered.  The company lost over 500,000 in fiscal 2023.  At this point further cuts are not anticipated.  We will be strategically adding positions that will enhance our profits. Hard work is expected of everyone."   Her two web guys had been complaining because their games had been remotely uninstalled.  After the memo came out they were absolutely silent.  That gave her an idea, and after an exchange of emails they were reassigned to maintenance out at the plant, effective tomorrow morning.  There were lots of weeds that needed pulling, if nothing else. That email went out after they left early, for the day.  The maintenance foreman was a no-nonsense type who did not tolerate slacking, and they would learn a thing or two.  This also freed up two spaces for her to put new people.
    • Davie
      Except for this thung thwister: Theophilus Thistle, the successful thistle sifter, in sifting a sieve full of unsifted thistles, thrust three-thousand thistles through the thick of his thumb. Now if, Theophilus Thistle, the successful thistle sifter, in sifting a sieve full of of unsifted thistles, thrust three-thousand thistles through the thick of his thumb, how many thistles can'st thou thrust through the thick of thy thumb . . . in sifting a sieve-full of unsifted thistles? Success to the successful thistle sifter!
    • VickySGV
      You have given you and us a big clue right there.  I hope you have shared this observation with your Endocrinologist and are willing to take their advice about changing that behavior.    Non prescribed herbal or animal supplements can have a negative effect on your body's use of your available hormones.  Also, your genetics are going to be controlling what your body is going to do with your hormones, and again, that is for you to consult with your Endocrinologists.  On this site none of us are licensed medical personnel and we cannot give you advice on your health more than what your doctor can.  We have rules that we enforce against our members advising about "Folk Remedies" because we have had members who have gone that route and badly damaged their health and quality of life.  Only thing I can go anywhere on, is that maybe if you change your expectations of what should happen, you will at least not be in danger of harming yourself from anxiety.
    • Timi
      Hi @violet r!    Thank you so much for sharing. I'm so glad you found this place. I hope you find as much comfort and support here as I have.    -Timi    
    • marysssia
      Hi lovely people,   I'm a 25 yo MtF woman, and I've been suffering from low estrogen issues since October 2023. I completely lost my feminine libido, my breast completely stopped growing, my estrogen levels dropped by a lot (despite NOT decreasing my E dosage) and thus my dysphoria drastically increased. I think it is worth mentioning that, for my health issues, I had been taking ----- Lamotrigine for months & had been on ketogenic diet, and these things seem to be a culprit of my current issue. I weaned off Lamotrigine some time ago and gave up on keto diet, but it still doesn't seem to help. My estrogen is still low (44 ng/ml) and my libido hasn't come back yet. In general, I struggle with my dysphoria so much because of that and, to be honest, I don't know what to do. I've tried so many dietary supplements, yet I didn't get any effects from them. My endocrinologist didn't know how to help me. She only suggested to increase my daily estrogen dose (to 3x per day ------sublingual estrogen tablets and 3x per day ------ estrogen gel applied to armpits or thighs), which I did, without any effect.   Please, help me. Prior to keto diet & Lamotrigine treatment, I'd never had experience like that. I'm basically helpless and have no clue what to do. Having to deal with low estrogen is a horrible experience to me and it affects my life severely.   BTW, my T levels are always within female range.   Do you have any clue what exactly I should do?
    • April Marie
      I love wearing a jeans skirt!! That looks like airport carpet. Safe travels if you're flying!!
    • Maddee
      Flight faraway forthcoming Fabulous forum friends 😊😊🎸🦂
    • Maddee
    • KathyLauren
      One of our cats is polydactyl.  He has 7 toes on each front paw and 5 on each back paw, for 24 toes total.   Another one, an ex-feral who, at the time, was free to roam, climbed 50 feet up a tree without having any thought about how he was going to get down.  His pal climed down backwards, but he couldn't.  He ended up coming down by leaping from branch to branch.  Which nearly gave us heart attacks, because he only has one eye and therefore has no depth perception.   The other ex-feral (both are now indoor cats) obviously does not have those soft pads on his feet.  At night, when we are in bed, we can hear him stomping around the house.
    • Abigail Genevieve
      The two o'clock Onshoring meeting was going well.  Taylor was leading, inviting other people up to speak on their specialties. Aerial photogrammetry and surveying, including the exact boundary, were out for contract signature  Gibson had handled that - Manufacturing was supposed to, but somehow hadn't happened.  Legal issues from Legal. Accounting reported on current costs, including all upkeep, guard salaries, etc.  Manufacturing was supposed to give those numbers, but they hadn't.   The downside was the VP of Manufacturing.  He had arrived at the meeting red-faced, his tie askew, clutching a bottle. It smelled strongly of vodka. He had never done anything in his twenty years of being VP of Manufacturing, and he did not like being asked now.   "Mr. ----, do you have the inventory we asked for?" Taylor asked politely.  VP Gibson had asked him to have his people go through the plant and not only inventory but assess the operational status of every piece of equipment.  They needed to know what they had. "I'm not going to take any f---- orders from a g-d- tra---," he snarled. "God knows what kind of perverts it has dragged into our fair city and bangs every night." "That is completely out of line." That was Gibson.  Taylor controlled herself.  That was a shot at Bob, not just at Taylor.  She was glad Bob was not there to do something stupid.  Had Mrs. McCarthy been talking? What had she said?  Was she given to embellishment?  Taylor took a deep breath. "I'm not sorry.  You f--- can take this stupid onshoring --- and shove it up your -" "That is quite enough."  This was the head of HR. "You can take your sissy ways and sashay -" "You are fired." "You can't fire me." "Oh, yes I can," said the office manager.  The VP took another swig from his bottle. "Try it."  He looked uncertain. "I will have you removed.  Are you going to leave on your own?  I am calling the police to help you leave." And he dialed the number. He stomped out cursing. They heard him noisily go down the hall.  This was the front conference room.  He actually went through security and out the door, throwing his badge on the ground on his way.  The guard picked it up. They could see this through the glass wall. "Can you fire a VP?" "The Board told me that if anyone gives me problems they should be shown the door. Even a VP.  I can fire everyone here. I won't, of course. Those were problems." "Are you alright, Taylor?" She nodded.  "I've heard worse.  Shall we continue?" And they did.   The last item was that certain business people in China had been arrested, and the corporation that had been supporting them all these years had been dissolved.  They were on their own, and the Board was dead serious on straightening things out.  After this meeting, Taylor believed it.  She did not attend the meeting to discuss how to distribute the few duties the VP of Manufacturing had done.  That was ultimately up to the Board.    
  • Upcoming Events

Contact TransPulse

TransPulse can be contacted in the following ways:

Email: Click Here.

To report an error on this page.

Legal

Your use of this site is subject to the following rules and policies, whether you have read them or not.

Terms of Use
Privacy Policy
DMCA Policy
Community Rules

Hosting

Upstream hosting for TransPulse provided by QnEZ.

Sponsorship

Special consideration for TransPulse is kindly provided by The Breast Form Store.
×
×
  • Create New...