Crazy mood swings?

[Guest Kiley Michelle]

After a month in on spironolactone, finasteride, and estradiol, I began taking an oral medroxyprogesterone pill (progesterone is the female hormone present at high levels in females during the period and pregnancy) and have been for the past two months.

I take the progesterone for ten days out of the month.

My mother and my friends can tell you, during the weekish I take the progesterone, I turn into a ridiculously moody, abnormally aggressive person. I can be super hapy one moment, but then my phone falls out of my pocket and the whole world might as well have blown up. Or I'll be watching t.v. and some little something will trigger a memory or thought which will set me off bawling.

Has anyone else had anything like this happen with Medroxyprogesterone?

[Guest Leah1026]

Not to sound like a broken record but...

Medroxyprogesterone does not have progesterone in it. It has a synthetic progestin (similar, but different) in it. A lot of people have trouble tolerating it, so it's not just you. Many of those people are forced to stop using Medroxyprogesterone because of the mood swings and anxiety issues. The alternative is taking bio-identical micronized progesterone. Besides being identical to what's in the human body naturally, it has a much lower incidence of side effects.

[Guest Donna Jean]

Not to sound like a broken record but...

Medroxyprogesterone does not have progesterone in it. It has a synthetic progestin (similar, but different) in it. A lot of people have trouble tolerating it, so it's not just you. Many of those people are forced to stop using Medroxyprogesterone because of the mood swings and anxiety issues. The alternative is taking bio-identical micronized progesterone. Besides being identical to what's in the human body naturally, it has a much lower incidence of side effects.

Absolutely!

I told my doctor how it was affecting me and she told me to quit taking it....

I've seen no physical benefit at all from it.....

Donna Jean

[Guest maisy2987]

After a month in on spironolactone, finasteride, and estradiol, I began taking an oral medroxyprogesterone pill (progesterone is the female hormone present at high levels in females during the period and pregnancy) and have been for the past two months.

I take the progesterone for ten days out of the month.

My mother and my friends can tell you, during the weekish I take the progesterone, I turn into a ridiculously moody, abnormally aggressive person. I can be super hapy one moment, but then my phone falls out of my pocket and the whole world might as well have blown up. Or I'll be watching t.v. and some little something will trigger a memory or thought which will set me off bawling.

Has anyone else had anything like this happen with Medroxyprogesterone?

1. What is finasteride? I just began estradiol and spironolactone, but I've never heard of it.

2. What are supposed to be the benefits of a progesterone?

I'm mostly also wondering this since my endocrinologist is pediatric (though I don't need a pediatric endo since I'm past puberty... so I could have started seeing my endo in town and saved a ton of time...) and has only worked with pre- or just starting puberty patients I don't know if I have different needs.

[Guest Melanie54]

Actually I would like to chime in here as my endo put me on medroxyprogesterone. He is having me use it as an anti androgen. I am a bit curious as to whether or not I should perhaps seek a second opinion. I take it every day not just a week a month. :/ I tolerate it well enough, no mood swings so far, but I don't think I've seen a perscription like this.

[Guest mistygirl7]

I take Medroxyprogesterone , I was prescribe to take it every day not just 10 days. It been doing well, I have nit had any side effect to that is IV been taking it for two years as well as spirolactone and estrodiol. My dosage are as high as my doctor will go.

[Guest Juniper Blue]

I have a female body (one ovary) and I take progesterone to balance abnormally high levels of estrogen. So this inforamtionmay not be helpful but then again .... it may be of some use. I take bio-identical progesterone that I have made at a compounding pharmacy. I was warned by my Doctor that non-bio-identical progesterone may have a higher risk for cancer and stroke. I was told by my pharmamict that too high of a dose of Progesterone can cause depression ... it can cause a strong sedative effect as well ... (this seems to happen with me.) I have a history of head injury and I do find that progesterone has a beneficial affect on my overall brain function ( you may want to look up Progestrone therapy and traumatic head injury to learn more about this.) Still .. there are health risks ... even with bio-identical hormones ... Progesterone can lead to an increase risk of stroke, blood clots etc. and so, I take the very lowest dose that I can. I am actually taking a break right now as I recover from a double mastectomy.

As far as taking an Aromatase inhibitor, I take a natural supplement called Indole 3 Carbinol or DIM ... it is derived from cruciferous vegetables like Broccoli. I have no idea how different biochemistry effects all of this ..... but ask your Doctor and research what you can if you are interested in learning more.

I, personally would only take HRT if absolutely necessary ... if I can function without the Progesterone, I will stop taking it permanently.

Good Luck .... I hope this basic information leads to more research and answers.

JB