Jump to content
  • Welcome to the TransPulse Forums!

    We offer a safe, inclusive community for transgender and gender non-conforming folks, as well as their loved ones, to find support and information.  Join today!

Any Insight on Taking Spironolactone Without Estrogen?

Recommended Posts


Does anyone have some insight on taking spironolactone without any additional estrogen or other replacement hormone medication? I am in a unique situation where my endocrinologist says I need to jump on spiro ASAP for a non-transitioning reason, but she wants me to wait for at least 6 months (and likely up to a year) to add female hormones. While I am fighting a bit of depression about having to wait for estrogen, I feel like I should be happy getting the "side effects" of spiro so soon while being treated for my other health issues. I was just wondering if anyone else is taking spironolactone alone, what benefits / side effects seem to really happen from the standard grocery list, and if there is any news or research about taking it for a longer period without introducing another hormone. Thank you for helping out! 🙂

Link to post
  • Admin

Spiro disables Testosterone as a useful side effect if you are being treated for high blood pressure or some water retention issues.  It is a potassium sparing diuretic, which means it keeps your body from ejecting potassium which is needed for health in many ways.  I was put on it because another diuretic was killing my potassium levels and giving me rather terrible cramp problems.  Our bodies even as AMAB produce some natural Estrogen which can get our breast development going for us and do some fat shifting.  The jury is out as to whether it would do the whole job if left alone, but the doctor who prescribed it to me was careful to explain the negative effects on my maleness, since I had not come out to him at that point I had to suppress a real silly giggle.  A couple of months later he did find out, and basically I was his first Trans patient, but he did support me when I did start E under the guidance of an Endocrinologist who was helping him in qualification on Diabetes which I had.  All good, you may be pleasantly surprised, I do know Cis males who have been unpleasantly surprised by it.

Link to post

@VickySGV Thank you for responding. This is what I was hoping to hear from my favorite forum but know each person has their own experience too. Doctors and web resources have to include everything which makes sorting out the "noise" a little difficult at times. I'm definitely not disappointed about going on spiro, but I was a little worried about having to wait for estrogen for so long, especially if my T drops to zero really fast. The one thing I am hearing - including from my doctor - is that I can't be hormone free for too long without some consequences (osteoporosis and other things might crop up if I did). If I am lucky enough to have a similar reaction like yours though, I will be happy with the "bad" side effects until I can add the estrogen boost next year. I'll keep you informed about the results as they happen! 🙂

Link to post
  • Forum Moderator


10 hours ago, Kathy2020 said:

hormone free for too long

It is the long term that you need to worry about Kathy.  
It will take some time for Spiro to have it's effect.  Be sure you drink a lot!  I also made a point of trying to limit foods containing a great deal of potassium.  If you get cramps more i found more fluids helped.  I remember drinking a gallon of green tea every day.  As Vicky noted  you may certainly experience some feminizing effects.  At the least your body will quickly accept E when you start up.  

I found that much of the medical community looks at the studies showing the dangers of progesterone treatment and don't want to start E for that reason.  Topical E delivery is the safest.  I have found that quite acceptable.  

Keep up your communication with your doctor.  

You are embarking on an amazing journey.  Fasten your seatbelt.





Link to post

At the first clinic I went to before the VA, they wouldn't give me E because of my age.  It was a policy across the board.  But they did give me Spiro.   For me personally, it caused my sodium levels to tank.  Later we tried another time with the same result.  I think it's my own personal issue though as others have done fine.  I would suggest keeping up with your blood work though.


Now, with the VA,  I'm on estradiol with no blockers.  

Link to post
15 hours ago, Charlize said:

Be sure you drink a lot!

I already have a couple friends lined up at the pub and margarita mix at the house... oh, wait... did you mean water? 🤭


15 hours ago, Charlize said:

At the least your body will quickly accept E when you start up.

My endocrinologist thinks that will happen, and I'm keeping my fingers crossed. I just don't want to do any damage while my T is wiped out and waiting for something to replace it. While a year seems long to me, I think you are right by saying I should be OK. Past a year though, and I think I will be pressuring my doctor for something just to make sure I stay healthy.


Getting back to drinking a lot, does it have to be water or can it be something like cranberry juice and vodka? 😄  

Link to post

Yeah I started Spiro and E at the same time alone with progesterone. 

I am still on E( injection), Progesterone  and  after my Orchiectomy ( 6 months ago) my Spiro went  down to one pill every week but after this month I should be off.

My problem is I was still get aroused even do I am down to zero Testosterone and being on E for 3yrs, and had Orch six months ago  So the Doc thought it be good to go back on for a few more weeks.


I get severe cramps when i drink Alcohol. I try to drink more walk.

I exercise a lot 4 to 5 times a week and i feel the weakness creeping in which i hear is another side effect of Spiro and Progesterone.

I am also 58 so maybe that has something to do with it

Just keep your Doc in the loop and make sure to get your Blood work done every 3 to 4 months.

Be Safe, Stay  PRoud and KICK ASS 

Link to post
  • Forum Moderator
10 hours ago, Kathy2020 said:

I already have a couple friends lined up at the pub and margarita mix at the house... oh, wait... did you mean water? 🤭


Both my therapist and doctor were very happy that i was active in AA and had some time in sobriety.  As Lexi noted alcohol is not a healthy part of HRT.  Alcohol acts a diuretic so if you drink plan to take more non alcoholic fluids.  






Link to post
Willow Farmer

Hi Kathy,

  I know you are asking about spironolactone, but my concerns are getting down to no hormones.   I am a prostate cancer survivor and my body doesn't make T any more.   I'm on mono therapy estradiol valerate.   when I had knee replacement I went for a month w/o hormones.   By the 3rd week the hot flashes and mental and mood failure were devastating.   I know of other people who can run on empty with 4 flat tires, but not me.   I hope it works out OK for you.   We can all celebrate your first month of estradiol with you.   I'm sure you will be chatty about it when it happens.


Willow McKenzie

Link to post
11 hours ago, Lexi C said:

I exercise a lot 4 to 5 times a week and i feel the weakness creeping in

This was the first concern my doctor said to watch out for when I start spiro since T is so vital to maintaining muscle mass. After that, it's upping my water intake and watching potassium levels to avoid muscle cramps, etc. She said things like breast development will be hit or miss until I add estrogen because spiro doesn't trigger a "second puberty" on its own. That totally made sense to me...

Link to post
5 hours ago, Charlize said:

... alcohol is not a healthy part of HRT ...

I agree with that and will expand it to say any of us dealing with anxiety, depression, and other emotional issues should be really conscious of the effects of alcohol. I didn't mean to imply otherwise, and was only poking a little fun at your earlier comment reminding me to "drink a lot!" The help group I often see always talks about our drinking problems... primarily the copious amounts of coffee, tea, and water we all consume to counteract the effects of medications, etc. Its the main reason we can't go anyplace more than short walk to the nearest bathroom! 😄

Link to post
5 hours ago, Willow Farmer said:

I know of other people who can run on empty... but not me.

Yes, this is my concern to... and I don't know if I am one of those or need a little go-go juice in the system to stay balanced. I guess I am about to find out! 😊

5 hours ago, Willow Farmer said:

We can all celebrate your first month of estradiol... I'm sure you will be chatty about it when it happens.

Oh lord, is that a side effect too? If it is, I'll need to warn my help group ahead of time! 🤣

Link to post

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
  • Who's Online   4 Members, 0 Anonymous, 71 Guests (See full list)

    • Shellianne_Kay83
    • Cyndee
    • AG1025
    • Charlize
  • Recently Browsing   0 members

    No registered users viewing this page.

  • Topics With Zero Replies

  • Forum Statistics

    • Total Topics
    • Total Posts
  • Member Statistics

    • Total Members
    • Most Online

    Newest Member
  • Today's Birthdays

    1. Luca
      (25 years old)
  • Posts

    • Charlize
      Perhaps simply knowing i'm not alone has been as important in finding self acceptance as anything else.  My feelings about gender and how i express it have certainly changed over time.  Some of that was societal pressure while some was simply due to life's pressing needs.  For much too long i felt shame and guilt for being myself.  Acceptance, whether of a distinct straight path or a winding trail, can take away self condemnation.      My life seems to wind and vary in many ways including my gender.  I've been hyper male, quite female and perhaps today i'm a "tomboy".  Truck and tractor driving farmer who puts on a skirt to go grocery shopping.  I just enjoy being me even if that is in flux.     Hugs,   Charlize
    • MetaLicious
      @Willow, I definitely thik the dog thing is offensive.  Not only does it show blatant disrepct for transfolk, there's an unhealthy dose of fat-shaming there as well.   As for female impersonators, drag queens have a disproportionate share of gays and transwomen compared to society, and are more "like us" than you may realize.  Also, I think Ru Paul is a treasure who has shown me how beautiful a man can be feminine even without transitioning.  He gives me hope.  He also has some pretty inspirational music!
    • Teri Anne
      Everyone is looking wonderful in the recent pics.
    • Jandi
      Sounds like a wise man. I'm sorry for you and your family.   It's never easy, even when you are expecting it.
    • Delcina B
      Solly, I'm glad you found the forum. I've found it to be a wonderful place full of caring people who share their experience, give advice & support, & accept me just as I am. I think you will find it so as well. This gender journey isn't a race, so you can take all the time you need, relax & breathe. Where we fit on the gender spectrum is where we find we feel comfortable, some are fluid & don't fix themselves with a specific label. It's all up to you.   Welcome! Delcina
    • Shay
      @Willow those are legitimate gripes and I concur. Wish people would respect others differences and not try to find humor where it's not.
    • Willow
      Good morning everyone.  Rain predicted for here in the top of Virginia today and tomorrow.   I have a question for ya’ll.  I get offended by some things which I feel are taking a shot at us.  For example, a joke on Facebook showed a fat dog and the caption was “I identify as trans slim”.  Or I don’t like female impersonators.  They are nothing like us yet they were allowed to advertise their show on on a transgender only secret website.  Am I overly sensitive?  Is it wrong to feel these sorts of things are offensive to me?  Let me know what you think.   @Elizabeth Star I was a Jack! Now Jill of all trades.  Made furniture, repaired the house and car, replaced a roof, you name it ive probably done it.  But I’m getting older and muscle mass is lessened.  My last project was definitely not up to my standard so I’m done.  Giving my stationery power tools to my son.  Gave away or sold a lot of stuff during our move out.  And will likely have more to deal with after we move in to our new place.  And my eyesight, very frustrating and upsetting when I can’t see clearly.  Nothing is ever at the correct focal distance.     let me know if I’m being overly sensitive with things I think are slaps at us.   Willow  
    • Shay
      @Elizabeth Star now that you have experience how about doing my and Cyndee's doors ?
    • Elizabeth Star
      I would be so mad if I broke a nail working on this stuff. I could hire someone to do the work but since I know what's involved I have trouble trusting other people's quality.
    • TiredAndScared
      Thank you all of course. I will get over it.  It's just that it's still a pain when it happens. That sounds kinda heartless but well....   to be brutally  honest.... that wasn't my dad anymore the last few years. It's his body of course.  But not him.. It was that, with every visit, he was a little bit more gone... So we already kinda said goodbye to him during the last 5 years or so. He could't recognize anyone anymore and couldn't do anything anymore..  For him it's sort of a good thing i guess....  He wouldn't want to be kept alive like this... Most things are already arranged by now... Cards have been picked and texts have been chosen. Dad is brought home in a coffin and ... what is the English term?...  laid out? (that sounds weird google translate) Just he's now presentable for anyone who wants to say goodbye. But it will be a week before he will get cremated. Mom still has her ankle operation going on tomorrow. So i have to get up early to bring her to the hospital.   Today i remembered something my dad thought me while i was a kid... Forgotten it for the longest time but .... He once told me:   "i don't care what you do with your life, be a president or a garbage collector. Just be happy with what you do" Not sure how old i was... somewhere between 10~12 years or something? I should keep that teaching in my life...  I know he mend it for my work career but i should apply it to my whole life...   Anyways,  for now i'm going to chill a bit. Woke up at 04am and with everything that happend i got a bit tired. 
    • Kris-Boston
      Just a link.  But being informed is best and real sources .  Its not an easy read ,for most . I was a  science major .   nejm.org   The New England Journal of Medicine: Research & Review Articles on Disease & Clinical Practice (nejm.org)
    • Bri2020
      Liz you're a jill of all trades it seems! I'm done with that kinda stuff.  I know how to fix most things, but I started pawning tht out to contractors about 7 years ago.  I used my back issues as the excuse but in reality, I just don't want to do all the "fix it up" stuff anymore. (especially after a manicure haha).  I think people have also started changing their expectations of me as well.  People use to come to me for help with all the "manly trades" but no one in the last year has except to borrow a tool or something.  My neighbor didn't even ask for my help building his deck (I've built 20 by now) even though I offered to help back before my transition.  We used to help each other with things like that. It's not like he isn't comfortable with my transition, he and his wife have been amazingly supportive and his Oklahoma courtesies of "Yes Ma'am" never fail to tickle me but he is definitely not going to ask a woman for help with carpentry. haha I find myself slipping into my feminine stereotypes more and more and I like it . 
    • Kris-Boston
      More of the news had a DR Zoom appointment Friday,  something in the New England Journal of Medicine  and from the research from Israel.  While no vaccine is 100 percent effective , its the non vaccinated who are at risk .   More of sources where to look .  While less of a personal touch I like the DR Zoom as no need to drive or take the T or pay to park near Fenway .  
    • Elizabeth Star
      On yesterday's episode of: A woman's Work is Never Done.   On my way how from work mt partner called to let me know her mother bought us a new back door. The original door was very old, beat up and had almost zero insulation value. We knew it had to be replaced, I just didn't want to do it "right now". I got home just in time to take five-er before there was knock on the door. In walks my MIL, FIL and BIL. Before I knew it, I was tearing out the old door. The door faces West and we're on a hill so I spent the next 5 hours roasting in the afternoon sun. Thankfully I didn't have all the trim that's needed so I was able to call it quits after the door was and frame were mounted. Plan is to get the final trim work done this morning and then back to cutting up the trees I dropped last weekend.   For you amusement I included a picture, my partner took, of me while I was working and of the newly installed door.    
    • Bri2020
      @Niamh looking cute as always! @Emily MicheleAdorable!  I'm glad to hear you're healing well. You must be on top of the world!
  • Upcoming Events

Contact TransPulse

TransPulse can be contacted in the following ways:

Email: Click Here.

To report an error on this page.


Your use of this site is subject to the following rules and policies, whether you have read them or not.

Terms of Use
Privacy Policy
DMCA Policy
Community Rules


Upstream hosting for TransPulse provided by QnEZ.


Special consideration for TransPulse is kindly provided by The Breast Form Store.
  • Create New...