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Odds of prostate cancer in post-HRT trans women


Dana Michelle

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Dana Michelle

Does anyone have any idea what the odds are of transgender women getting prostate cancer? Prostate cancer runs in my family. I asked my endocrinologist and she said there has not been enough research to determine the odds. I wonder if there is at least anecdotal reports of what the odds are. Does anyone know? I found an article that said there have only been four reported cases of prostate cancer in transgender women, all of which started HRT after age 45 (I started at 36) https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00439-8/fulltext. However, there could be many more unreported cases.

 

I do plan to have prostate cancer screening once I am 50 years old, but I am still wondering if anyone has any idea what the odds are. Given that 1 in 7 cis men (and presumably pre-HRT trans women) gets prostate cancer, it seems like if the odds were as high for post-HRT trans women, it would be known. Also, does anyone know how the odds of post-HRT trans women getting prostate cancer compares to cis women getting Skene's gland cancer? I read that Skene's gland cancer makes up 1 in 30000 female genital cancers, but that doesn't say what the odds are of cis women (and presumably, pre-HRT trans men) getting it (just the odds that, if a cis woman will get genital cancer, it will be in the Skene's gland).

 

Also, for the sake of trans men, it would also be worth asking what the odds are of post-HRT trans men getting Skene's gland cancer.

 

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Dana I don't believe there has much study on this subject.  I am one of those 1 in 7 that got it and had it rectified years ago.  I would think (my opinion only) that taking estrogen would lessen the chances.  I've read anecdotal evidence that it shrinks testes so it might also affect this gland as well.

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1 hour ago, Dana Michelle said:

Does anyone have any idea what the odds are of transgender women getting prostate cancer? Prostate cancer runs in my family. I asked my endocrinologist and she said there has not been enough research to determine the odds. I wonder if there is at least anecdotal reports of what the odds are. Does anyone know? I found an article that said there have only been four reported cases of prostate cancer in transgender women, all of which started HRT after age 45 (I started at 36) https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00439-8/fulltext. However, there could be many more unreported cases.

 

I do plan to have prostate cancer screening once I am 50 years old, but I am still wondering if anyone has any idea what the odds are. Given that 1 in 7 cis men (and presumably pre-HRT trans women) gets prostate cancer, it seems like if the odds were as high for post-HRT trans women, it would be known. .

 

 

As Jani, I have had prostate cancer. I had the surgery to remove it and 2 years later ADT + radiation. It also runs in my family. I am not a doctor, but have talked to people on almost every English speaking prostate cancer website out there. I am on Lupron, which shuts down testosterone and estrogen, except from the adrenal glands. It causes both the testes and the prostate to shrink if you still have them. Odds of cancer should be substantially reduced at your age by HRT, but not to zero. I have no idea how it compares to Skene's gland cancer

 

Hugs,

Mike

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I've read that it reduces your risk, but as others have said, there haven't been a ton of studies. I couldn't tell you exactly how much.

 

We're hard to study considering that we're on the rare side and kind of reclusive. Like bigfoot.

 

Hugs!

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